CLINICAL STUDY REPORT: AN OVERVIEW OF REGULATORY DOCUMENTS AND THE ORGANIZATIONAL AND PRACTICAL ASPECTS OF DEVELOPMENT

CLINICAL STUDY REPORT: AN OVERVIEW OF REGULATORY DOCUMENTS AND THE ORGANIZATIONAL AND PRACTICAL ASPECTS OF DEVELOPMENT

Clinical study report is one of the main documents during Desk the drug development.The preparation of the clinical study report requires knowledge of Russian and foreign legislation, awareness of guidelines and recommendatioins issued by the professional associations as well as the effective process management.This article provides an overview of

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Can ultrasound measures of intrinsic foot muscles and plantar soft tissues predict future diabetes-related foot disease? A systematic review.

INTRODUCTION:Diabetes mellitus (DM) is associated with hyperglycaemia and advanced glycosylation end-products.In the foot, the consequences of chronic or uncontrolled diabetes are micro and macrovascular disease, neuropathy, reduced joint mobility and structural and soft tissue changes that increase the risk of ulcer development and amputation.Diab

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The Evolution of the Cooperation between South American Countries in the Amazon Basin: From the Development of the Amazon Cooperation Treaty to the Signing of the Leticia Pact for the Amazon

This article is focused on special characteristics of formation and development of the interaction between South American countries located on the territory of the Amazon Basin from the development of the Amazon Cooperation Treaty (ACT) in 1978 to the signing of the Leticia Pact Powerboard Enclosue for the Amazon in 2019.Considering the evolution o

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